Ondine Study Shows Reduction of Endotracheal Tube Biofilm Using Photodisinfection

Ventilator-associated pneumonia is one of the most common and deadliest forms of healthcare-associated infections.  In the U.S alone, more than one million patients in healthcare facilities require mechanical ventilation every year. Up to 1 in 4 of these patients are reported to develop ventilator-associated pneumonia and up to half of them will die.1

Antimicrobial photodynamic therapy (aPDT), commonly known as Photodisinfection, is a non-invasive technique that used to study the reduction of biofilm in the lumen of an endotracheal tube. When patients undergo mechanical ventilation, an endotracheal tube is inserted into their throat to assist with breathing. This tube has long been recognized as a major factor in a patient’s risk for developing biofilm infections. For patients that require mechanical ventilation, such as those in ICUs, the biofilm can dislodge from the endotracheal tube and enter the lungs directly, often resulting in difficult-to-treat pneumonia.

In order to more closely simulate an actual human clinical study environment, a simulated clinical model was developed for testing. In this study, MRSA and multidrug-resistant Pseudomonas aeruginosa were grown in a bacterium broth and circulated through an endotracheal tube for 48 hours, coating the lumen.  Following this, a small amount of photosentizing solution was sprayed inside the tube and activated with a laser light, initiating the photodisinfection process. The results of this study showed that after a single treatment using Photodisinfection, a significant reduction of endotracheal tube biofilm was observed (more than 3 log reduction (P<0.005) from the baseline).

Photodisinfection is a non-invasive and non-antibiotic approach in eradicating biofilm from the endotracheal tube without removing it from the body.  Ventilator-associated pneumonia is the #1 most common healthcare-associated infection in intensive care units and is one of the largest contributors of prolonged hospital stays, increased costs, and increased patient morbidity in hospitals.

The Photosidisinfection system developed in this study was designed to prevent and control the growth of biofilm within the endotracheal tube, and would therefore be planned for use 24 hrs after a patient is mechanically ventilated, and every 8 hrs thereafter. To read the full study, please go to  http://onlinelibrary.wiley.com/doi/10.1002/lsm.21103/abstract

  1. Davis et al. Ventilator-Associated Pneumonia: A Review. Journal of Intensive Care Medicine July 2006. Vol 21 (4): 211-226
Related Posts Plugin for WordPress, Blogger...

Leave a Reply

Staypressed theme by Themocracy