Ondine’s Photodisinfection Technology Being Developed To Treat Chronic Sinusitis

Photodisinfection is a highly effective antimicrobial therapy involving non-thermal light and a topically placed photosensitizer. It is currently being used for the treatment of oral infections and nasal decolonization of MRSA and S. aureus. Photodisinfection is also being currently used for the treatment of endotracheal tube biofilms to prevent ventilator associated pneumonia. One of the areas of medical need identified for photodisinfection is for the treatment of chronic sinusitis that has failed surgical and medical therapies. It is estimated that there are more than 500,000 of these people suffering in the US alone, and this number grows by 10% annually.

Polymicrobial biofilms, many of them antibiotic resistant, have been significantly implicated in the etiology of this chronic indolent disease process and its associated inflammatory processes.  Preclinical studies we have conducted demonstrate the effectiveness of photodisinfection to selectively photoeradicate a broad spectrum of biofilm micoorganisms, including antibiotic resistant S. aureus, P. aerugenosa and fungal species, without causing injury to tissue or mucosa.

Sinuwave Technologies Corp has developed light administration devices that would allow for “in office” treatment of chronic sinusitis patients.  This is designed as a painless, repeatable therapy that can be performed with only topical nasal anaesthesia. This unique treatment modality is expected to undergo human trials in the second half of 2012 in Canada. To learn more about  www.sinuwave.com

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