Posts tagged: aPDT

Ondine Congratulates Dr. Bryon Bhagwandin For Presenting His Research At The International AIDS Society Conference 2011

The use of Photodisinfection to disinfect the birth canal is a novel approach that can bypass the stigma associated with HIV treatment and any reliance on patient compliance.

Ondine is pleased to congratulate Dr. Bryon Bhagwandin of Vitalwave™ on the publication of his abstract at the International AIDS Society (IAS) Conference. This is an important accomplishment as it highlights the need to develop new approaches in preventing mother-to-child HIV transmission.

A higher vaginal HIV viral load has been independently associated with a higher risk of transmission. Dr. Bhagwandin’s study evaluated the use of antimicrobial Photodynamic Therapy (aPDT), also known as Photodisinfection, as a means to reduce the vaginal viral load of pregnant women infected with HIV/AIDS. In 2008, more than 1.4 million pregnant women were living with this disease. An additional 430,000 children had been infected through mother-to-child transmission.

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Study Using Periowave™ Shows Rapid Resolution Of Aggressive Periodontitis

We’re pleased to announce today that the results of a study involving antimicrobial Photodynamic Therapy (aPDT), or Photodisinfection, were presented at the 13th International Photodynamic Association World Congress. This study, conducted by Dr. Veronique Benhamou, evaluated the use of the Periowave™ Photodisinfection System in the treatment of an aggressive case of periodontitis.

The current standard of care for aggressive periodontitis involves scaling and root planing in conjunction with antibiotic therapy. The subject of this study received scaling and root planing followed by aPDT (PeriowaveTM) in place of any antibiotic therapy.  This protocol produced rapid, clinically significant results and no adverse events were reported.  The significance of the results was confirmed through standard clinical tests and x-rays.

Periowave™ is a painless, non-invasive procedure that can significantly improve treatment outcomes when added to scaling and root planing.

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Photodynamic Disinfection (PDD) is the Antimicrobial application of PDT (aPDT)

The key features of aPDT can be summarized as follows [1]:

  • Broad spectrum of action, since one photosensitizer can act on bacteria, fungi, yeasts and parasitic protozoa
  • Efficacy independent of the resistance pattern of the given microbe
  • Extensive reduction of pathogen counts in minutes, without damaging host cells
  • No selection of resistant strains after multiple treatments
  • Readily available, non-toxic photosensitizers
  • Relatively low-cost light sources for activation of the photosensitizing agent
  • No cytotoxic effects on key sensitive host cells such as human keratinocytes or fibroblasts

The treatment of topical infections has traditionally relied upon antibiotics in either topical or systemic dosage forms. However, the inexorable increase in antibiotic resistance (including to vancomycin and other glycopeptides) has led to the spectre of potentially untreatable infections, and this in turn has led to the development of alternative antimicrobial approaches based on light-activated chemotherapy 2, 3. Photodynamic Disinfection (called antimicrobial PDT by the scientific community) is an extension to traditional photodynamic therapy (PDT) which was originally focused on oncotherapy and intra-ocular indications, utilizing systemically-administered photosensitizers. Read more »

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