Posts tagged: Clostridium difficile

It Took Half A Century To Develop A C. Difficile Treatment

It has taken 50 years, but a new drug has been released as a treatment for infections caused by Clostridium difficle. The new drug, called Dificlir, is an antibiotic treatment that has been shown to cut the chances of relapse from this type of infection in half.

C. diff, a gram-positive bacteria that can cause a serious and potentially fatal infection of the colon, can be found naturally in the gut flora of approximately 3% of adults and two-thirds of children. As a part of the body’s natural flora, the bacteria can live without causing any problems. For those who have experienced the painful and explosive symptoms of such infections, which include extreme diarrhea and abdominal pain, the release of this new drug is great news. It is also significant considering that C. diff has become more virulent over the past few decades, evolving into a key player in the emerging threat of antibiotic resistance.

The new drug works by preventing C. diff bacteria from producing the toxins that cause the disease and its immobilizing symptoms. By preventing such symptoms, the drug inadvertently prevents others from contracting the disease, as microbes are less likely to spread in the absence of the explosive diarrhea. It has taken over ten years to develop this new type of antibiotic, which is also called fidaxomicin.

Read more »

A Silent Epidemic: A Documentary That Could Save Your Life

In August of 2008, I lost my father to a number of healthcare-associated infections including C. diff, MRSA, and pseudomonas. As I began my freshman year at Providence College the following week, I started doing research to learn more about what happened to my dad, and what I learned astonished me. HAIs infect approximately 1.7 million individuals annually in the United States alone, killing nearly 99,000 of those who become infected. I also learned that these infections are largely preventable.

As I learned more about healthcare-associated infections, I knew I had to do something to help bring that information to others. The perfect opportunity arose when I became a film minor, with the hope of eventually making a film to raise awareness. In January of 2012, I contacted Pat Mastors, who I had met the winter after my dad passed away. Pat lost her father in 2007 as a result of C. diff, and has since become a huge advocate for patient safety and awareness, creating the Patient Pod, which is a tool to help keep patients safe in hospitals, nursing homes, and other related environments. She has also been an immense help in the production of this film, as she put me in contact with a number of individuals across the country, and also set up my interview with Dr. David Lowe, an infectious disease specialist who saved the life of one of her close friends. Dr. Lowe’s interview was also immensely helpful, as he explained complicated scientific information in a way that the average person can easily understand.

Read more »

The Three Myths About Photodisinfection

I’ve talked before about how photodisinfection works, but I want to take a moment to clarify what I think are the three most common myths about the technology we’re working on here at Ondine.

It’s Not That New

Our products are often met with scepticism because people are unfamiliar with photodisinfection as a treatment, or even as a science.  Truth be told, photodisinfection has existed for over 100 years[i], and the research behind it has a solid foundation in the literature extending back well over 20 years.  Check out this short reference list if you don’t believe me. So why, with all this research, is photodisinfection only creeping into the marketplace now?  The simple answer is that, until Ondine, most companies have been a little hesitant to put the work in to make it a success.  Photodisinfection requires a lot from a company: an engineering team for a light source, a microbiology team for the preclinical tests, a chemistry team for the careful formulation of the photosensitizer and a regulatory team to get the product cleared for use in trials and approved clinical use.  When you add in quality control, finance, administration, and sales and marketing, you can see the inherent challenges facing a company. You can trust me that the science is there (and growing), and Ondine has proven that it has what it takes to make these products a reality.

Read more »

Related Posts Plugin for WordPress, Blogger...

Staypressed theme by Themocracy