Posts tagged: infection control

How does Photodisinfection Work?

Photodisinfection is a topical, non-antibiotic antimicrobial therapy that destroys a broad spectrum of pathogens including fungi, bacteria and virus without damaging human tissue. Unlike antibiotics, Photodisinfection selectively kills virulence factors such as the endotoxins and exotoxins produced by pathogens, leading to a clinically observable anti-inflammatory effect. The treatment process takes only minutes, making it over 1,000 times more effective at biofilm killing than antibiotics.

Photodisinfection is a minimally invasive non-thermal therapy involving the light activation of a photosensitizer to eliminate topical infections in a highly targeted approach. Photodisinfection has been proven to be safe and effective in other applications such as for the dental, sinusitis and hospital acquired infection prevention markets. In dentistry, Photodisinfection has been proven to be highly effective for the treatment of caries, endodontics, restorative dentistry, periodontitis, peri-implantitis and halitosis. Many new applications of Photodisinfection are now under development.

The Photodisinfection Process: Instant Antimicrobial Therapy

Apply Photosensitizer to Infection Site & Illuminate with Appropriate Wavelength for Several Minutes

A photosensitizing solution is applied to the treatment site where the photosensitizer molecules preferentially bind to the targeted microbes.  The photosensitizer molecules are inactive at this stage.  A light of a specific wavelength and intensity illuminates the treatment site and a photocatalytic reaction occurs.  The wavelength is carefully chosen to maximize absorption of light energy by the photosensitizer.

This 2 step procedure results in the destruction of the targeted microbes and their virulence factors without damaging host cells.  This reaction involves the formation of short-lived, highly reactive free-radical oxygen species.  These radicals cause a physical disruption of the microbial cell membrane through oxidative reactions, resulting in immediate rupture and destruction of the cell.  This process occurs in seconds with total kills completed in minutes.

The Photodisinfection process has also been shown to eliminate a multitude of virulence factors, unlike antibiotics. When the light isremoved, the photocatalytic reaction ceases along with all antimicrobial action. Photodisinfection does not promote the development of resistance.

The Photodisinfection process is both pain-free and stress-free due to lack of side-effects or damage to human tissue.

Source: Eastman Dental Institute, UK

The Growing Temptation to Underreport Healthcare-associated Infections

Over the past decade, there has been much written about the rise of antibiotic resistant pathogens and the growing numbers of serious healthcare-associated infections. Some statistics have put the total cost of healthcare-associated infections at around $35-$45 billion dollars1. Infections associated with MRSA have been estimated to cost about $3-$4 billion2 and ventilator-associated pneumonia costs another $3 billion3. The truth is that we really do not know the extent of the problem or the associated costs, and this in itself is a problem. Whatever the number, we can all agree that the costs of healthcare-associated infections are an enormous drain on the economy, and this is prior to factoring in any of the socio-economic multiplier effects of HAIs due to death, loss of employment, impact on families/companies etc.

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Ondine To Participate in Vancouver General Hospital Infection Control Project

MRSAid product by Ondine Biomedical

World Health Day is celebrated on the 7th of April every year to mark the establishment of the World Health Organization (WHO). Each year, the WHO selects a key health issue and encourages people from around the world to hold events and promote actions that will improve health. It is very fitting for Ondine then that this year’s World Health Day theme is “Combating Drug Resistance.” We have spent the last 70 years using and misusing antibiotics to treat and prevent common infectious diseases. Today, we have entered an era where bacteria have developed the ability to become resistant to most antibiotics, rendering them almost useless. It is therefore imperative that non-antibiotic solutions to fight infections are developed in order to preserve the next generation of effective medicine. Read more »

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