Posts tagged: Photodisinfecion

How does Photodisinfection Work?

Photodisinfection is a topical, non-antibiotic antimicrobial therapy that destroys a broad spectrum of pathogens including fungi, bacteria and virus without damaging human tissue. Unlike antibiotics, Photodisinfection selectively kills virulence factors such as the endotoxins and exotoxins produced by pathogens, leading to a clinically observable anti-inflammatory effect. The treatment process takes only minutes, making it over 1,000 times more effective at biofilm killing than antibiotics.

Photodisinfection is a minimally invasive non-thermal therapy involving the light activation of a photosensitizer to eliminate topical infections in a highly targeted approach. Photodisinfection has been proven to be safe and effective in other applications such as for the dental, sinusitis and hospital acquired infection prevention markets. In dentistry, Photodisinfection has been proven to be highly effective for the treatment of caries, endodontics, restorative dentistry, periodontitis, peri-implantitis and halitosis. Many new applications of Photodisinfection are now under development.

The Photodisinfection Process: Instant Antimicrobial Therapy

Apply Photosensitizer to Infection Site & Illuminate with Appropriate Wavelength for Several Minutes

A photosensitizing solution is applied to the treatment site where the photosensitizer molecules preferentially bind to the targeted microbes.  The photosensitizer molecules are inactive at this stage.  A light of a specific wavelength and intensity illuminates the treatment site and a photocatalytic reaction occurs.  The wavelength is carefully chosen to maximize absorption of light energy by the photosensitizer.

This 2 step procedure results in the destruction of the targeted microbes and their virulence factors without damaging host cells.  This reaction involves the formation of short-lived, highly reactive free-radical oxygen species.  These radicals cause a physical disruption of the microbial cell membrane through oxidative reactions, resulting in immediate rupture and destruction of the cell.  This process occurs in seconds with total kills completed in minutes.

The Photodisinfection process has also been shown to eliminate a multitude of virulence factors, unlike antibiotics. When the light isremoved, the photocatalytic reaction ceases along with all antimicrobial action. Photodisinfection does not promote the development of resistance.

The Photodisinfection process is both pain-free and stress-free due to lack of side-effects or damage to human tissue.

Source: Eastman Dental Institute, UK

How Ondine Biomedical Addresses A World Of Growing Antibiotic Resistance

In 1969, the US Surgeon General William Stewart declared that the human race had won the war against bacteria. It was thought that bacteria would never be able to figure out how to develop resistance to the new complex antibiotics that had been created and that scientific researchers would always be able to stay well ahead of the bacteria. Today, it is well known that bacteria have reversed this situation and that the antibiotic resistance war is far from being over.

It is estimated that there are about 17 million people in the US alone annually suffering from painful and potentially harmful biofilm infections. To me and my colleagues at Ondine, we understand that certain bacteria have become dangerous and remain a threat to all of us. Every single one of us knows of a person who died, or nearly died, of an infection. Many of these people have died from infections acquired while in hospitals, a place where most of us think is safe. This just was not the case 20 years ago. This prevalence of deadly infections could not have been expected in 1969.  Our society’s overuse and misuse of antibiotics (over 25 million pounds of antibiotics are given to livestock every year) have led to greater threats to humanity. At the same time, the enormous costs and regulatory burdens have led to fewer new antibiotics being developed. Clearly the battle rages and we as humans have not been very strategic about our critical weapons. Read more »

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