Posts tagged: Photodynamics

Ondine’s Photodisinfection Technology Being Developed To Treat Chronic Sinusitis

Photodisinfection is a highly effective antimicrobial therapy involving non-thermal light and a topically placed photosensitizer. It is currently being used for the treatment of oral infections and nasal decolonization of MRSA and S. aureus. Photodisinfection is also being currently used for the treatment of endotracheal tube biofilms to prevent ventilator associated pneumonia. One of the areas of medical need identified for photodisinfection is for the treatment of chronic sinusitis that has failed surgical and medical therapies. It is estimated that there are more than 500,000 of these people suffering in the US alone, and this number grows by 10% annually.

Polymicrobial biofilms, many of them antibiotic resistant, have been significantly implicated in the etiology of this chronic indolent disease process and its associated inflammatory processes.  Preclinical studies we have conducted demonstrate the effectiveness of photodisinfection to selectively photoeradicate a broad spectrum of biofilm micoorganisms, including antibiotic resistant S. aureus, P. aerugenosa and fungal species, without causing injury to tissue or mucosa.

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Working at Ondine: A Career Leading To A Harvard MBA

December 14, 2010 was a really special day for me. I was in my office when I got the news – I had been accepted to Harvard Business School’s MBA program. Now, as my time at Ondine comes to an end, I’ve been asked to recount my story, and how I got to the enviable position of being able to leave a job that I love for an unbelievable opportunity.

I began at Ondine in January of 2008 after returning from a backpacking trip around Western Europe. I had secured the internship the summer beforehand, and viewed it as the perfect opportunity. I had always been interested in business, but I was convinced that I would be attending dental school, having written the entrance examinations during my undergraduate degree. Ondine, having a commercially available dental product, was the hybrid I was looking for. So, armed with only my UBC degree in Cell Biology and Genetics, I set off to see what business was all about. Read more »

Photodynamic Disinfection (PDD) is the Antimicrobial application of PDT (aPDT)

The key features of aPDT can be summarized as follows [1]:

  • Broad spectrum of action, since one photosensitizer can act on bacteria, fungi, yeasts and parasitic protozoa
  • Efficacy independent of the resistance pattern of the given microbe
  • Extensive reduction of pathogen counts in minutes, without damaging host cells
  • No selection of resistant strains after multiple treatments
  • Readily available, non-toxic photosensitizers
  • Relatively low-cost light sources for activation of the photosensitizing agent
  • No cytotoxic effects on key sensitive host cells such as human keratinocytes or fibroblasts

The treatment of topical infections has traditionally relied upon antibiotics in either topical or systemic dosage forms. However, the inexorable increase in antibiotic resistance (including to vancomycin and other glycopeptides) has led to the spectre of potentially untreatable infections, and this in turn has led to the development of alternative antimicrobial approaches based on light-activated chemotherapy 2, 3. Photodynamic Disinfection (called antimicrobial PDT by the scientific community) is an extension to traditional photodynamic therapy (PDT) which was originally focused on oncotherapy and intra-ocular indications, utilizing systemically-administered photosensitizers. Read more »

Cancer: A Fact of Life

It used to be that cancer was a rare condition; something one saw only in the movies or heard about in books. That is how it used to be when I was growing up in the 1960’s & ’70’s. By the time the ’80’s rolled around, cancer had reached my neighbourhood, but still did not affect me directly. I would hear of the odd case of a school chum’s mother or grandfather dying from this disease. Over the years, however, I would come to hear of more and more people around me having cancer. Read more »

Photodisinfection for the treatment of Biofilm Infections

Bacteria, which are single-celled organisms, generally exist in either a free-floating, unattached (planktonic) state or in an attached state called a biofilm.  A planktonic form suggests these single celled organisms float or swim independently of each other in some liquid medium.  A biofilm, or attached state, is created with a change of behaviour triggered by many factors, including quorum sensing. A biofilm is a complex community of a number of different microorganisms coexisting together and marked by the excretion of a protective and adhesive matrix. The biofilm is held together and protected by the matrix, called extracellular polymeric substance or exopolysaccharide (EPS), holds the biofilm together, protects the cells within it and facilitates communication among bacteria through biochemical signals.  In a biofilm, cells are closely packed together and firmly attached to each other and usually to a solid surface. Read more »

Professor Michael Wilson

Michael Wilson

Michael Wilson

Michael Wilson, GRSC, MSc, PhD, DSc, FRCPath

Pro-Provost for Europe, UCL

Professor of Microbiology, Eastman Dental Institute, University College London

I would like to take this opportunity to pay tribute to Professor Wilson and to share with you why he is well deserving of this recognition. In this day of Hollywood induced hero worship, there is insufficient recognition paid to the true heroes among us. Far too much attention is given to the wrong kinds of people, in my view, and not enough on those who make a real and lasting difference to mankind. Professor Wilson is a true global hero as his innovative work will lead to many lives saved and much human suffering alleviated. Read more »

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